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Sporadic amyotrophic lateral sclerosis

MedGen UID:
400171
Concept ID:
C1862941
Disease or Syndrome
Synonym: Amyotrophic Lateral Sclerosis, Sporadic
 
Monarch Initiative: MONDO:0005145
OMIM®: 105400

Definition

Sporadic amyotrophic lateral sclerosis is a amyotrophic lateral sclerosis in which there is no known cause, such as no family history. [from MONDO]

Professional guidelines

PubMed

Lattante S, Marangi G, Doronzio PN, Conte A, Bisogni G, Zollino M, Sabatelli M
Genes (Basel) 2020 Sep 24;11(10) doi: 10.3390/genes11101123. PMID: 32987860Free PMC Article
Dekker AM, Seelen M, van Doormaal PT, van Rheenen W, Bothof RJ, van Riessen T, Brands WJ, van der Kooi AJ, de Visser M, Voermans NC, Pasterkamp RJ, Veldink JH, van den Berg LH, van Es MA
Neurobiol Aging 2016 Mar;39:220.e9-15. Epub 2015 Dec 29 doi: 10.1016/j.neurobiolaging.2015.12.012. PMID: 26777436
Swash M, Leigh N
Neuromuscul Disord 1992;2(1):7-9. doi: 10.1016/0960-8966(92)90020-7. PMID: 1356048

Recent clinical studies

Etiology

Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group
J Neurol Neurosurg Psychiatry 2023 Oct;94(10):816-824. Epub 2023 May 4 doi: 10.1136/jnnp-2022-330851. PMID: 37142397
Van Daele SH, Moisse M, van Vugt JJFA, Zwamborn RAJ, van der Spek R, van Rheenen W, Van Eijk K, Kenna K, Corcia P, Vourc'h P, Couratier P, Hardiman O, McLaughin R, Gotkine M, Drory V, Ticozzi N, Silani V, Ratti A, de Carvalho M, Mora Pardina JS, Povedano M, Andersen PM, Weber M, Başak NA, Shaw C, Shaw PJ, Morrison KE, Landers JE, Glass JD, van Es MA, van den Berg LH, Al-Chalabi A, Veldink J, Van Damme P
Brain 2023 Sep 1;146(9):3760-3769. doi: 10.1093/brain/awad120. PMID: 37043475Free PMC Article
Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA
Nat Med 2021 Apr;27(4):640-646. Epub 2021 Apr 15 doi: 10.1038/s41591-021-01295-9. PMID: 33859435Free PMC Article
Yilihamu M, He J, Liu X, Tian J, Fan D
Neurobiol Aging 2021 Jun;102:224.e1-224.e3. Epub 2021 Feb 7 doi: 10.1016/j.neurobiolaging.2021.01.028. PMID: 33714647
VanItallie TB
Metabolism 2019 Nov;100S:153943. doi: 10.1016/j.metabol.2019.07.007. PMID: 31610856

Diagnosis

Van Daele SH, Moisse M, van Vugt JJFA, Zwamborn RAJ, van der Spek R, van Rheenen W, Van Eijk K, Kenna K, Corcia P, Vourc'h P, Couratier P, Hardiman O, McLaughin R, Gotkine M, Drory V, Ticozzi N, Silani V, Ratti A, de Carvalho M, Mora Pardina JS, Povedano M, Andersen PM, Weber M, Başak NA, Shaw C, Shaw PJ, Morrison KE, Landers JE, Glass JD, van Es MA, van den Berg LH, Al-Chalabi A, Veldink J, Van Damme P
Brain 2023 Sep 1;146(9):3760-3769. doi: 10.1093/brain/awad120. PMID: 37043475Free PMC Article
Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA
Nat Med 2021 Apr;27(4):640-646. Epub 2021 Apr 15 doi: 10.1038/s41591-021-01295-9. PMID: 33859435Free PMC Article
VanItallie TB
Metabolism 2019 Nov;100S:153943. doi: 10.1016/j.metabol.2019.07.007. PMID: 31610856
Eisen A, Braak H, Del Tredici K, Lemon R, Ludolph AC, Kiernan MC
J Neurol Neurosurg Psychiatry 2017 Nov;88(11):917-924. Epub 2017 Jul 14 doi: 10.1136/jnnp-2017-315573. PMID: 28710326
Statland JM, Barohn RJ, McVey AL, Katz JS, Dimachkie MM
Neurol Clin 2015 Nov;33(4):735-48. Epub 2015 Sep 8 doi: 10.1016/j.ncl.2015.07.006. PMID: 26515618Free PMC Article

Therapy

Kumar R, Malik MZ, Thanaraj TA, Bagabir SA, Haque S, Tambuwala M, Haider S
Cell Signal 2023 Dec;112:110915. Epub 2023 Oct 13 doi: 10.1016/j.cellsig.2023.110915. PMID: 37838312
Ly CV, Ireland MD, Self WK, Bollinger J, Jockel-Balsarotti J, Herzog H, Allred P, Miller L, Doyle M, Anez-Bruzual I, Trikamji B, Hyman T, Kung T, Nicholson K, Bucelli RC, Patterson BW, Bateman RJ, Miller TM
Ann Clin Transl Neurol 2023 Jun;10(6):1012-1024. Epub 2023 Apr 29 doi: 10.1002/acn3.51784. PMID: 37119480Free PMC Article
Aizawa H, Kato H, Oba K, Kawahara T, Okubo Y, Saito T, Naito M, Urushitani M, Tamaoka A, Nakamagoe K, Ishii K, Kanda T, Katsuno M, Atsuta N, Maeda Y, Nagai M, Nishiyama K, Ishiura H, Toda T, Kawata A, Abe K, Yabe I, Takahashi-Iwata I, Sasaki H, Warita H, Aoki M, Sobue G, Mizusawa H, Matsuyama Y, Haga T, Kwak S
J Neurol 2022 Feb;269(2):885-896. Epub 2021 Jun 30 doi: 10.1007/s00415-021-10670-y. PMID: 34191081Free PMC Article
Mendez EF, Sattler R
Brain Res 2015 May 14;1607:26-35. Epub 2014 Sep 27 doi: 10.1016/j.brainres.2014.09.041. PMID: 25261695
Li M, Wang L, Wang W, Qi XL, Tang ZY
Braz J Med Biol Res 2014 Feb;47(3):215-22. Epub 2014 Feb 18 doi: 10.1590/1414-431X20133296. PMID: 24604426Free PMC Article

Prognosis

Gascón E, Zaragoza P, Calvo AC, Osta R
Biomolecules 2024 Mar 20;14(3) doi: 10.3390/biom14030377. PMID: 38540795Free PMC Article
Kumar R, Malik MZ, Thanaraj TA, Bagabir SA, Haque S, Tambuwala M, Haider S
Cell Signal 2023 Dec;112:110915. Epub 2023 Oct 13 doi: 10.1016/j.cellsig.2023.110915. PMID: 37838312
Zamiri K, Kesari S, Paul K, Hwang SH, Hammock B, Kaczor-Urbanowicz KE, Urbanowicz A, Gao L, Whitelegge J, Fiala M
FASEB J 2023 Aug;37(8):e23068. doi: 10.1096/fj.202300573R. PMID: 37436778Free PMC Article
Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group
J Neurol Neurosurg Psychiatry 2023 Oct;94(10):816-824. Epub 2023 May 4 doi: 10.1136/jnnp-2022-330851. PMID: 37142397
Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA
Nat Med 2021 Apr;27(4):640-646. Epub 2021 Apr 15 doi: 10.1038/s41591-021-01295-9. PMID: 33859435Free PMC Article

Clinical prediction guides

Baskerville V, Rapuri S, Mehlhop E, Coyne AN
Brain 2024 Jan 4;147(1):109-121. doi: 10.1093/brain/awad291. PMID: 37639327Free PMC Article
Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA
Nat Med 2021 Apr;27(4):640-646. Epub 2021 Apr 15 doi: 10.1038/s41591-021-01295-9. PMID: 33859435Free PMC Article
VanItallie TB
Metabolism 2019 Nov;100S:153943. doi: 10.1016/j.metabol.2019.07.007. PMID: 31610856
French PW, Ludowyke R, Guillemin GJ
Neurotox Res 2019 May;35(4):969-980. Epub 2018 Dec 5 doi: 10.1007/s12640-018-9980-5. PMID: 30515715
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J
Science 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803. PMID: 27493188Free PMC Article

Recent systematic reviews

Daneshafrooz N, Joghataei MT, Mehdizadeh M, Alavi A, Barati M, Panahi B, Teimourian S, Zamani B
Sci Rep 2022 Jan 26;12(1):1373. doi: 10.1038/s41598-022-05067-4. PMID: 35082326Free PMC Article
Newell ME, Adhikari S, Halden RU
Sci Total Environ 2022 Apr 15;817:152504. Epub 2021 Dec 28 doi: 10.1016/j.scitotenv.2021.152504. PMID: 34971691
Pecoraro V, Mandrioli J, Carone C, Chiò A, Traynor BJ, Trenti T
Eur J Clin Invest 2020 May;50(5):e13228. Epub 2020 May 19 doi: 10.1111/eci.13228. PMID: 32293029Free PMC Article
Sutedja NA, Veldink JH, Fischer K, Kromhout H, Heederik D, Huisman MH, Wokke JH, van den Berg LH
Amyotroph Lateral Scler 2009 Oct-Dec;10(5-6):302-9. doi: 10.3109/17482960802455416. PMID: 19922117
Sutedja NA, Fischer K, Veldink JH, van der Heijden GJ, Kromhout H, Heederik D, Huisman MH, Wokke JJ, van den Berg LH
Amyotroph Lateral Scler 2009 Oct-Dec;10(5-6):295-301. doi: 10.3109/17482960802430799. PMID: 19922116

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